Detalhe da pesquisa
1.
Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis.
J Enzyme Inhib Med Chem
; 37(1): 781-791, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35193444
2.
Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles.
Bioorg Med Chem Lett
; 37: 127843, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556576
3.
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies.
Parasitology
; 147(11): 1216-1228, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32530391
4.
Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi.
Parasitol Res
; 117(11): 3367-3380, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232605
5.
In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives.
Parasitology
; 143(1): 34-40, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26525913
6.
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.
Parasitology
; 143(11): 1469-78, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27312370
7.
Novel solid dispersions of benznidazole: preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system.
Exp Parasitol
; 149: 84-91, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583295
8.
Trypanocidal Activity of Long Chain Diamines and Aminoalcohols.
Molecules
; 20(6): 11554-68, 2015 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26111182
9.
In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents.
Bioorg Med Chem Lett
; 24(4): 1209-13, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24461296
10.
Antiprotozoan lead discovery by aligning dry and wet screening: prediction, synthesis, and biological assay of novel quinoxalinones.
Bioorg Med Chem
; 22(5): 1568-85, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513185
11.
Further insights into biological evaluation of new anti-Trypanosoma cruzi 5-nitroindazoles.
Parasitol Res
; 113(3): 1049-56, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24435615
12.
Selective activity of 2,4-diaryl-1,2,3,4-tetrahydroquinolines on Trypanosoma cruzi epimastigotes and amastigotes expressing ß-galactosidase.
Bioorg Med Chem Lett
; 23(17): 4851-6, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899616
13.
Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites.
J Med Chem
; 66(19): 13452-13480, 2023 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37729094
14.
5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents.
Acta Trop
; 234: 106607, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35907502
15.
Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds.
Bioorg Med Chem
; 19(15): 4562-73, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21723734
16.
New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors.
J Biomol Screen
; 13(8): 785-94, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18753687
17.
Activity of a hydroxybibenzyl bryophyte constituent against Leishmania spp. and Trypanosoma cruzi: in silico, in vitro and in vivo activity studies.
Eur J Med Chem
; 43(9): 1797-807, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18192088
18.
Drug repositioning for novel antitrichomonas from known antiprotozoan drugs using hierarchical screening.
Future Med Chem
; 10(8): 863-878, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29589477
19.
Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines.
ChemMedChem
; 13(12): 1246-1259, 2018 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29624912
20.
New Imidazole-Based Compounds Active Against Trypanosoma cruzi.
Comb Chem High Throughput Screen
; 20(1): 20-24, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28071587